The insurer said it would offer plans through 2017, but that the market has not stabilized enough to participate next year.
Humana said it was losing money from taking on too many sick people without enough healthy people to balance the pools.
The decision came after Humana scaled back participation and raised premiums, among other changes.
"All of these actions were taken with the expectation that the company’s Individual Commercial business would stabilize to the point where the company could continue to participate in the program," the company said in a statement.
"However, based on its initial analysis of data associated with the company’s healthcare exchange membership following the 2017 open enrollment period, Humana is seeing further signs of an unbalanced risk pool."
“Therefore, the company has decided that it cannot continue to offer this coverage for 2018. Through the remainder of 2017, Humana remains committed to serving its current members across 11 states where it offers Individual Commercial products. And, as it has done in the past, Humana will work closely with its state partners as it navigates this process.”
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